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Novel property effecting and/or property exhibiting compositions for therapeutic and diagnostic use

机译:用于治疗和诊断用途的新型性质影响和/或性质表现组合物

摘要

The present invention provides an array of compositions useful for effecting and/or exhibiting changes in biological functioning and processing within cells and in biological systems containing such cells. In effect, these compositions combine chemical modifications and/or ligand additions with biological functions. The chemical modifications and/or ligand additions provide additional characteristics to the compositions without interfering substantially with their biological function. Such additional characteristics include nuclease resistance, targeting specific cells or specific cell receptors localizing to specific sites within cells and augmenting interactions between the compositions and target cells of interest as well as decreasing such interactions when desired. Also provided by the present invention are processes and kits.
机译:本发明提供了一系列组合物,其可用于实现和/或展示细胞内以及包含这种细胞的生物系统中的生物学功能和加工的变化。实际上,这些组合物将化学修饰和/或配体添加与生物学功能结合在一起。化学修饰和/或配体添加为组合物提供了额外的特性,而基本上不干扰它们的生物学功能。这样的附加特征包括核酸酶抗性,靶向特定细胞或位于细胞内特定位点的特定细胞受体,并增强组合物和目标靶细胞之间的相互作用以及在需要时减少此类相互作用。本发明还提供了方法和试剂盒。

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