IL24 for inducing hyperproliferative or autoimmune cell death

摘要

The invention concerns the use of IL24 for the treatment of a hyperproliferative or autoimmune disorder by inducing death of hyperproliferative or autoimmune cells, in particular through stimulation of p53 expression. The invention also relates to a a kit comprising IL24 and a cytokine likely to trigger hyperproliferative or autoimmune cells into cell cycle as a combined preparation for sequential use for the treatment of a hyperproliferative or autoimmune disorder. The invention further provides an inhibitor of activated-Stat3 for treating chronic lymphocytic leukaemia.