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PROTEOMIC ANALYSIS OF CERVICAL-VAGINAL FLUIDS FOR DETECTING INTRA-UTERINE INFECTION OR DETERMINING PRE-TERM DELIVERY RISK IN A PREGNANT FEMALE
PROTEOMIC ANALYSIS OF CERVICAL-VAGINAL FLUIDS FOR DETECTING INTRA-UTERINE INFECTION OR DETERMINING PRE-TERM DELIVERY RISK IN A PREGNANT FEMALE
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机译:宫颈阴道液的蛋白质组学分析,用于检测子宫内感染或确定孕妇的早产风险
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摘要
The invention concerns the identification of proteomes of biological fluids and their use in determining the state of maternal/fetal conditions, including maternal conditions of fetal origin, chromosomal aneuploidies, and fetal diseases associated with fetal growth and maturation. In particular, the invention concerns a comprehensive proteomic analysis of human amniotic fluid (AF) and cervical vaginal fluid (CVF), and the correlation of characteristic changes in the normal proteome with various pathologic maternal/fetal conditions, such as intra-amniotic infection, pre-term labor, and/or chromosomal defects. The invention further concerns the identification of biomarkers and groups of biomarkers that can be used for non-invasive diagnosis of various pregnancy-related disorders, and diagnostic assays using such biomarkers.
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