GAS-FILLED MICROVESICLES WITH TARGETING LIGAND IN RESPECT OF FC-REGION OF AN ANTIBODY OR THERAPEUTIC AGENT

摘要

Gas-filled microvesicles comprising a boundary envelope containing a gas, wherein said microvesicles comprise: a first component, bound to said envelope, having binding affinity for an Fc-region of an antibody; anda second component comprising a Fc-region of an antibody, bound to said first component through said Fc-region, said second component comprising a targeting ligand or a therapeutic agent. Aqueous suspensions of said microvesicles are particularly useful in contrast enhanced ultrasound imaging.