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Salmonella Mutants Deleted lon Gene and/or cpxR Gene and Live Salmonella Vaccines Comprising Thereof
Salmonella Mutants Deleted lon Gene and/or cpxR Gene and Live Salmonella Vaccines Comprising Thereof
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机译:沙门氏菌突变体已删除lon基因和/或cpxR基因以及包含沙门氏菌的活沙门氏菌疫苗
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摘要
An attenuated Salmonella live vaccine is provided to be easily and economically produced and stored and prevent Salmonella infection safely and efficiently when administered to a domestic animal. A method for preparing a Salmonella live vaccine comprises a step of deleting a lon or a cpxR gene from a chromosome DNA of a Salmonella strain such as Salmonella typhimurium, S. typhi, S. paratyphi, S. sendai, S. gallinarium and S. enteritidis. A vector includes a DNA where a DNA fragment linked to a 5'-terminal of the lon gene derived from the Salmonella strain and a DNA fragment linked to a 3'-terminal of the lon gene are bonded. An attenuated Salmonella vaccine composition comprises a Salmonella mutant where the lon gene and the cpxR gene are deleted from the chromosome DNA of the Salmonella and a pharmaceutically acceptable carrier.
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