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PHARMACEUTICAL COMPOSITION FOR PROMOTING OSTEOBLAST DIFFERENTIATION AND ACTIVITY COMPRISING URSOLIC ACID AND 2-alpha-HYDROXY-URSOLIC ACID
PHARMACEUTICAL COMPOSITION FOR PROMOTING OSTEOBLAST DIFFERENTIATION AND ACTIVITY COMPRISING URSOLIC ACID AND 2-alpha-HYDROXY-URSOLIC ACID
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机译:包含骨灰质酸和2-α-羟基-骨灰质酸的促进成骨细胞分化和活性的药物组合物
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摘要
A pharmaceutical composition including ursolic acid and 2-alpha-hydroxy-ursolic acid is provided to prevent and treat osteoporosis, fracture, periodontal diseases and bone growth disability. A pharmaceutical composition for promoting osteoblast differentiation and activities comprises ursolic acid represented by the formula 1 and 2-alpha-hydroxy-ursolic acid represented by the formula 2 as active ingredients. The ursolic acid and 2-alpha-hydroxy-ursolic acid are extracted from Prunella vulgaris through a column chromatography process. The amount of the ursolic acid and 2-alpha-hydroxy-ursolic acid is 0.0001-50wt% on a total weight basis of the pharmaceutical composition.
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