NEW BACILLUS SP. AH159-1, MACROLACTIN COMPOUNDS ISOLATED FROM THEM, PROCESS FOR PRODUCING THE SAME, AND ANTIBACTERIAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

摘要

Provided is a method for manufacturing a pharmaceutical compound including macrolactin, which has high-powered antibacterial activity about gram positive bacteria such as Staphylococcus aureus and Bacillus subtilis as well as gram negative bacteria such as Escherichia coli. A method for manufacturing a macrolactin based compound comprises the following steps of: cultivating bacillus genus AH159-1 strain(KCTC 11199BP); extracting a mycelium and a culture fluid of the obtained strain by acetone and performing a re-extraction process by ethylacetate; and separating the obtained ethylacetate extract by silica gel column chromatography.