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METHOD FOR SUPPRESSION OF ETHANOL EFFECT TO NEURON BY KNOCK DOWNED GAMMA-AMINO BUTYRIC ACID RECEPTOR B1
METHOD FOR SUPPRESSION OF ETHANOL EFFECT TO NEURON BY KNOCK DOWNED GAMMA-AMINO BUTYRIC ACID RECEPTOR B1
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机译：敲除γ-氨基丁酸受体B1抑制乙醇对神经元的作用
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摘要
A method for inhibiting nerve cell poisoning and anesthesia effect of ethanol by using knock downed GABAB1(gamma-amino butyric acid B1) receptor is provided to inhibit nerve cell poisoning and anesthesia effect by suppressing the expression of protein kinase A (PKA) within nerve cells and cAMP(Cyclic adenosine monophosphate)-CREB. A knock downed GABAB1(gamma-amino butyric acid B1) receptor using interference RNA is provided to inhibit poisoning and anesthesia effect to nerve cell of the ethanol. The interference RNA is complementarily bound with the transferred mRNA from 1097-1516th base of the GABAB1 receptor gene ofSEQ ID NO: 1.
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机译：提供了一种通过使用敲低的GABAB1（γ-氨基丁酸B1）受体抑制乙醇的神经细胞中毒和麻醉作用的方法，其通过抑制神经细胞内蛋白激酶A（PKA）的表达来抑制神经细胞中毒和麻醉作用。和cAMP（环状单磷酸腺苷）-CREB。提供了一种使用干扰RNA的敲低GABAB1（γ-氨基丁酸B1）受体，以抑制乙醇对神经细胞的中毒和麻醉作用。干扰RNA与来自SEQ ID NO：1的GABAB1受体基因第1097-1516位碱基的mRNA互补结合。
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