NEW CHIRAL RESOLVING AGENTS AND METHOD FOR ISOLATING CHIRAL ISOMER USING SAME

摘要

The present invention relates to a process for separating the optical isomers from a novel optical resolution agent and the racemic compound by using this represented by the general formula (1), this according to the invention (R, S) - of amlodipine racemate and (R, S) - it can be isolated in a simple way than the omeprazole-omeprazole from a racemic body of each of the optical purity is high (S) - amlodipine isomer and (S). ; Wherein ; R ₁ is an alkyl group having 1 to 9 other than t- butyl group, having 3 to 6 carbon atoms of the heterocyclic group, an aryl group, or a bromine, chlorine, nitro, trifluoromethyl, and substituted with one or more substituents selected from the group consisting of sulfonamide an aryl group, ; R ₂ is hydrogen, bromine, chlorine, nitro, trifluoromethyl, sulfonamide, alkyl having from 1 to 9 or an alkyl group having 1 to 9 carbon atoms in the alkoxy group of, ; N is an integer from 1 to 4, ; Dicarboxylic acid ester present in the basic frame group has a position ortho, meta or para. ; Racemic compound and optically active phthalyl acid derivatives