COMPOSITION COMPRISING A HUMAN ANTIBODY CAPABLE OF NEUTRALIZING HEPATITIS B VIRUS FOR PREVENTING OR TREATING HEPATITIS B VIRUS INFECTION

摘要

A therapeutic composition for preventing and treating hepatitis B virus(HBV) is provided to prevent HBV infection during the liver transplantation and prevent and treat the chronic hepatitis by using together with a viral replication inhibitor. An antibody composition for preventing and treating the hepatitis B virus(HBV) comprises an antibody containing a heavy chain variable region(VH) of the sequence number 1(SEQ ID NO:1) and a light chain variable region(VL) of the sequence number 2. The antibody is produced from a HBAb-49(KCLRF-BP-00054) cell line. An anti-virus agent is an interferon, anti-HBV monoclonal antibody, anti-HBV polyclonal antibody, nucleoside analogue, DNA polymerase inhibitor, or siRNA(small interfering RNA). The composition is applied into mammal including human. The daily dose of mammal is 0.001-10 mg/kg(weight).