COMPOSITION FOR INHIBITING THE ACTIVITY OF INOSITOL 1,4,5-TRIPHOSPHATE RECEPTOR SUBTYPE III

摘要

A composition for suppressing an inositol 1,4,5-triphosphate receptor subtype III is provided to prevent and treat diseases which is related to calcium ion release. An agent for suppressing a subtype III of inositol-1,4,5-triphosphate receptor comprises one or more among a group of caffeine, 7-isopropyl theophylline, 7-(beta-hydroxyethyl)theophyline, xanthenes, theophyline, 1,7-dimethyl-3-isobutyl xantene and their pharmaceutically allowable salt as active ingredient. A composition for preventing and treating diseases which is related to calcium ion excessive release comprises one or more among caffeine, 7-isopropyl theophyline, 7-(beta-hydroxyethyl)theopyline, xanthene, theophyline, 1,7-dimethyl-3-isobutyl xanthenes and their pharmaceutically allowable salt as active ingredient. The diseases related to calcium ion excessive release is one of stroke, anxiety, hyper sensitive bladder salt, inflammatory bowel disease, irritable colon syndrome, interstitial colitis, head injury, migraine, chronic, the neuropathy nature or the acute pain, the stress disorder after drug or the alcoholism, the neurological failure, psychosis, somnopathy, phobia, compulsion, debit, and the depression, stroma, diabetes, cancer, the male sterilization, hypertension, pulmonary hypertension, cardiac arrhythmia, congestive heart failure, angina, the polycystic kidney disease [autosomal dominant polycystic kidney] and Duchenne muscular dystrophy (DMD).