SOLID LIPID NANOPARTICLES FOR DRUG DELIVERY, A PROCESS FOR THE PREPARATRION THEREOF, AND AN INJECTION COMPRISING THE SAME

摘要

A solid lipid nanoparticle for drug delivery, which has a form containing a nano lipid nuclear is provided to have high stability of formulation and apply to hydrophilic drug, hydrophobic drug, and protein drug. A solid lipid nanoparticle for drug delivery has a nano lipid nuclear comprising a mixed lipid matrix of cacao butter and drug in a shell which is formed with poloxamer. The poloxamer is poloxamer 407, 124, 188, 235, 237, 238, 338 or their combination. The nano particle comprises 5-30 weight part of cacao butter based on the 100 weight of poloxamer and has 100-300 nm of average diameter. The solid lipid nanoparticle is used in a form of anticancer drug, or therapeutic agent for osteoporosis.