A method for isolating and expanding autologous antigen-specific CD8+ T cells using an anti-4-1BB antibody

摘要

The present invention relates to a separation method wherein -4-1BB and proliferation method of antigen-specific CD8 + T cells with antibodies, and more particularly, separation methods of CD8 + T cells, and proliferation of the present invention compared with the same method of separation methods showed a high cell sugeoyul even if the recovery rate is high and the cells, separating the antigen-specific cells using a humanized anti--4-1BB antibody, also exhibits a high proliferation in the culture process after separating the separation method of the invention, and the antigen-specific CD8 + T cells obtained by the growth method can be applied without side-effects in the treatment and improvement of the cancer disease. ; Wherein -4-1BB, CD8 + T cells, the separation method, Method proliferation, cancer