METHOD FOR PREPARING ?-CHIRAL NITRILE COMPOUND BY COPPER-CATALYZED REDUCTION OF ?,?-DISUBSTITUTED ?,?-UNSATURATED NITRILES

摘要

The present invention using a copper complex catalyst beta, beta-disubstituted alpha, beta-unsaturated nitrile compound relates to a method for producing a nitrile compound having a chiral center in beta position with the reduction method, more particularly, to a solvent and under the presence of copper complex catalyst of formula (I), - disubstituted , - unsaturated nitriles the compound as a reaction additive C ₂ ~ C ₆ on a chiral beta position of the formula (II) to a secondary or tertiary alcohol is added to the hydrochloride by reacting with silane reduction of relates to a process for producing a nitrile compound having a chiral center in beta position, characterized in that the nitrile to give the compound having the center. ; the production method of the present invention are copper (II) acetate as catalyst and bis-phosphine ligands and the use, by the use of hydrogen as the hydrochloride silane, beta, beta-disubstituted alpha, beta-unsaturated nitrile compound also faster than conventional methods, materials having a high stereo selectivity and yield can be reduced to, and thus various drugs and can be prepared a compound of formula (II) usable as an intermediate of a physiologically active substance.