Highly Enantioselective Conjugate Reduction of beta,beta-Disubstituted alpha,beta-Unsaturated Nitriles

摘要

Optically active nitrile compounds with a beta-stereocenter are versatile synthetic intermediates for a number of biologically active compounds.The nitrile group is a very useful synthetic group that can be transformed into other useful functionalities,such as amine,aldehyde,and carboxylic acid groups;furthermore,the isolation of nitrile-containing natural products continues to increase.