COMPOSITIONS AND METHODS FOR PREVENTING ERYTHROPOIETIN-ASSOCIATED HYPERTENSION

摘要

The present invention when administered to a mammal along with the erythropoietin (Epo), Epo without affecting the therapeutic purpose hematocrit standing dissolving erythropoietin which usually involves preventing or reducing the increase in blood pressure is by erythropoietin-binding proteins and soluble erythropoietin-binding It relates to antibodies to the protein. The invention and administration of erythropoietin (Epo) in the mammal; Comprising administering an agent selected from soluble Epo binding protein (Epo-bp), recognized protein and a complex thereof which bind to Epo receptors on the extracellular soluble portion of the Epo receptor in a mammal, methods for the treatment of anemia in a mammal It provides. The invention also a method of reducing the blood pressure in a mammal treated with Epo, and dissolved Epo-bp and / or a pharmaceutical composition containing a recognition protein that binds to the extracellular Epo receptors on the melting portion of the Epo receptor is also provided.