BRCA1 and BRCA2 germline mutations useful for predicting or detecting breast cancer or ovarian cancer

摘要

A BRCA1 and BRCA2 gene mutation is provided to detect breast cancer or ovarian cancer with low costs and high efficiency by providing the type of the mutation specific in Korean existing in the nucleotide sequential of BRCA1 and BRCA2. A polynucleotide consists of the 20-100 continuous nucleotide sequence. The 20-100 continuous nucleotide sequence includes a BRCA1 gene mutation selected from a group consisting of: the insertion of GGG and the deletion of AT in 38th base and 39th base in the polynucleotide consisting of the sequence of the sequence number 1; the substitution of 154th base from C to T in the polynucleotide consisting of the sequence of the sequence number 1; the substitution of 390th base from C to A in the polynucleotide consisting of the sequence of the sequence number 1; the substitution of 527th base from C to T in the polynucleotide consisting of the sequence of the sequence number 1; and the insertion of A between 720th base and 721th base in the polynucleotide consisting of the sequence of the sequence number.