DERIVATIVES OF ARYL (HETARIL) -3-AMINOMETHYLINOLONE-2 AS INHIBITORS OF NO-SYNTHETIZE AND CYCLOXYGENASE-2, METHODS OF THEIR PRODUCTION, BIOLOGICALLY ACTIVE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS BASED ON THEIR BASIS

摘要

1. Amino derivatives of aryl-3-aminomethylquinolone-2 of general formula (1): R1, R2, R3, R4 are independently the same or different and at least one of R1, R2, R3, R4 is selected from the group consisting of Alk, OAlk , Ar, OAr, CHCH, SAlk, F, Cl, Br, OCF, NO, NH, NHAlk, N (Alk); the other or other of R1, R2, R3, R4 are H, or R2 and R3 are taken together and are selected from (CH2) -, - (CH2) -, -OCO-, -OSCON-, for R1 and R4 being the same or different and selected independently from H, Alk, OAlk, Hal; R5 is independently selected from H or Alk; R6 is independently selected from H, Alk, CHNO; R7, R8, R10, R11 are independently the same or different and at least one, one of R7, R8, R10, R11 is selected from Alk, OAlk, CHOH, SAlk, Ar, OAr, F, Cl, Br, CF, OCF, COOR, COONRR, NRR, NHCOR, SONRR, NO; where R14, R15, R16, R17, R18, R19, R20, R21 are the same or different and are independently selected from H or Alk; the other or the other of R7, R8, R10, R11 are H; R9 is independently selected from H or from the following substituents: where (*) corresponds to the place of attachment of the bond of the substituent R9 to the phenyl moiety in formula (I); n = 1, 2 , 3 or 4; X is independently selected from OH or Alk; Y is independently selected from Alk, OAlk, Ar or Het; R22, R23 are independently selected from H, Alk, OAlk, SAlk, Hal, COOH, COOAlk, SOAlk, NO, CN ; R24, R25 are the same or different and are independently selected from H, Alk; R26 is independently selected from H or Alk; R27, R28 are independently selected from H, Alk, OAlk, Hal, NO, CN; or R8 and R9 are taken together and are selected from - (CH) -, - (CH) -, -OCHO-, -OCH2CH2-, with this R7, R11 are independently the same or different and are selected from H, Hal, NO; and R10 is H.R12, R13 are independently the same or different and are selected from the group consisting of H, Alk, Bz.2. The amino derivatives of aryl-3-aminomethylquinolone-2 according to claim 1, characterized in that they are selected from the group consisting of 3 - [(4-dimethylamino-phenylamino) methyl] -5,6,7-trimethoxy-1H-quinolin-2-one ; 3 - [(4-dimethylamine