NEW depot nucleoside with antiviral activity based on derivatives of phosphonic acid

摘要

1. Bis-nucleoside esters of phosphonic acids having the general formula: wherein Nu and Nu '- identical or different nucleoside analogs: Nu, Nu' = AZT, 3TC, ddC, ddI, d4T, abacavir, and t.p.R = alkyl group ( CC), including those containing halogen atoms (F, Cl, Br, I), carboxy, azido, amino, cyano, hydroxy, alkoxy and acyloxy, arylalkyl (benzylamine, phenylethylamine, and the like diphenylmethylamine .) and aminocarbonyl groups, including substituted alkyl (CC), cycloalkyl (CC), arylalkyl (benzylamine, phenylethylamine, diphenylmethylamine, etc.) and heterocyclic (morpholine Pieper Idin, pyrrole, piperazine, etc.) 2. Bis-nucleoside esters of phosphonic acids having the general formula: wherein Nu and Nu '- identical or different nucleoside analogs: Nu, Nu' = AZT, 3TC, ddC, ddI, d4T, abacavir, and t.p.R = alkyl group (CC) , including those containing halogen atoms (F, Cl, Br, I), carboxy, azido, amino, hydroxy, alkoxy and acyloxy, arylalkyl (benzylamine, phenylethylamine, diphenylmethylamine, etc.), as well as aminocarbonyl groups, including substituted alkyl (CC), cycloalkyl (CC), arylalkyl (benzylamine, phenylethylamine, diphenylmethylamine, etc.) and heterocyclic (morpholine, piperidine, feast roll, piperazine, etc.) both - depot forms antiviral nucleoside nature.