NOVEL DEPOT-FORMS OF ZIDOVUDINE AND LAMIVUDINE BASED ON PHOSPHONIC ACID DERIVATIVES

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to dinucleoside forms of phosphonic acids which can be used as antiviral agents, having formula where Azt is a 3'-azido-3'-deoxythymidine residue, ZTS - 2',3'-dideoxy-3'-thiacitidine residue, R is an electron acceptor group, for example ClCH₂-, CH₃C(O)CH₂-, H₂NCO-, PhCH₂CH₂HNCO-, PhOCH₂-, CH₃OCH₂-, N₃CH₂-.;EFFECT: obtaining novel antiviral agents.;1 cl, 3 ex, 2 tbl