BENZIMIDAZOLE DERIVATIVES AND THEIR APPLICATION FOR MODULATION OF THE RECEPTOR COMPLEX OF GAMMA-AMINOBUT ACID (GABA)

摘要

1. The compound of General formula (I):! ! or its N-oxide, any of its isomers, or any mixture of its isomers,! or a pharmaceutically acceptable salt thereof,! where! Ra, Rb and Rc independently of one another are hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, hydroxy, alkoxy, alkoxyalkyl, arylalkyl, formyl, alkylcarbonyl or alkoxyalkylcarbonyl; ! Rd represents a heteroaryl group; ! where the heteroaryl group is optionally substituted with one or more substituents independently selected from the group consisting of:! halo, hydroxy, R′R ″ N—, R′R ″ N-alkyl, cyano, nitro, trifluoromethyl, trifluoromethoxy, hydrazino, alkoxy, cycloalkoxy, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl and alkynyl groups; ! where R ′ and R ″ independently of one another are hydrogen or alkyl. ! 2. The compound according to claim 1, where Ra is hydrogen, alkyl or arylalkyl. ! 3. The compound according to claim 1, where Rb represents hydrogen, alkyl, alkoxy, arylalkyl, formyl or alkylcarbonyl. ! 4. The compound according to claim 1, where Rb represents hydrogen or alkyl. ! 5. The compound according to any one of claims 1 to 4, where Rd is a heteroaryl group selected from thiazolyl, pyridyl, pyrimidyl and pyrazinyl; ! wherein the heteroaryl group is optionally substituted with one or more substituents independently selected from the group consisting of halo, hydrazino and alkoxy. ! 6. The compound according to claim 1, representing! C- [1- (3-Thiazol-2-ylphenyl) -1H-benzimidazol-5-yl] methylamine; ! C- [1- (3-Pyridin-3-ylphenyl) -1H-benzimidazol-5-yl] methylamine; ! C- [1- (3- [6-Fluoropyridin-3-yl] phenyl) -1H-benzimidazol-5-yl] methylamine; ! C- [1- (3- [Pyridin-2-yl] phenyl) -1H-benzimidazol-5-yl] methylamine; ! C- [1- (3-Pyrazin-2-ylphenyl) -1H-benzimidazol-5-yl] me