TREATMENT OF SEVERE HOSPITAL PNEUMONIA USING THE TYPE FACTOR WAY INHIBITOR (TFPI)

摘要

1. A method of treating or preventing severe pneumonia, comprising administering TFPI or a TFPI analogue to a patient with or at risk of severe pneumonia by continuous intravenous infusion at a dose equivalent to administering a reference ala-TFPI at a dose of less than about 1.0 mg / kg / h; and however, the patient does not receive an anticoagulant within 24 hours from the introduction of TFPI or an analogue of TFPI. ! 2. The method according to claim 1, wherein the above TFPI analog is non-glycosylated ala-TFPI. ! 3. The method according to claim 1, in which the above patient has a proven infection. ! 4. The method according to claim 1, in which the above TFPI or TFPI analog is administered by continuous intravenous infusion in a dose equivalent to the introduction of a reference ala-TFPI in a dose of less than about 0.80 mg / kg / h. ! 5. The method according to claim 4, in which the above dose is equivalent to the introduction of a reference ala-TFPI at a dose of from about 0.025 to about 0.10 mg / kg / h and in which the above TFPI or TFPI analog is administered for at least about 72 hours .! 6. The method according to claim 5, in which the above dose is equivalent to the introduction of a reference ala-TFPI in a dose of from about 0.010 to about 0.10 mg / kg / h. ! 7. The method according to claim 6, in which the above TFPI analog is non-glycosylated ala-TFPI. ! 8. The method according to claim 6, in which the above dose is equivalent to the introduction of a reference ala-TFPI in a dose of from about 0.020 to about 0.08 mg / kg / h. ! 9. The method of claim 8, wherein the above TFPI analog is non-glycosylated ala-TFPI. ! 10. The method according to claim 1, wherein the aforementioned TFPI or the aforementioned TFPI analog is administered for at least about 96 hours! 11. The method of claim 10, wherein the above TFPI analog is non-glycosylated