BICYCLIC DERIVATIVES AND THEIR APPLICATION AS MODULATORS OF ION CHANNELS

摘要

1. The compound of formula I:! ! or a pharmaceutically acceptable salt thereof,! where the ring Z is a 5-7 membered unsaturated or aromatic ring containing at least one heteroatom in the ring selected from O, S, N or NH; ! wherein ring Z may optionally be fused to ring A, which is an optionally substituted 5-7 membered unsaturated or aromatic ring; and! ring Z or ring Z together with the aforementioned condensed ring A may be substituted by a number z of substituents Rz; ! z is 0-4; ! each Rz element is independently selected from R1, R2, R3, R4, or R5; ! q is 0-2; ! Q means a bond or a C1-C6 straight or branched alkylidene chain in which one or two non-adjacent methylene units of Q are optionally and independently substituted by -CO-, -CS-, -COCO-, -CONR2, -CONR2NR2-, -CO2-, - OCO-, -NR2CO2-, -O-, -NR2CONR2-, -OCONR2-, -NR2NR2-, -NR2NR2CO-, -NR2CO-, -S-, -SO-, -SO2-, -NR2-, -SO2NR2- , -NR2SO2-, -NR2SO2NR2- or the spirocycloalkylene part; ! RQ means a C1-6 aliphatic group, a 3-8 membered saturated, partially unsaturated or fully unsaturated monocyclic ring containing 0-3 heteroatoms independently selected from O, S, N or NH, or an 8-12 membered saturated, partially unsaturated or a completely unsaturated bicyclic ring system containing 0-5 heteroatoms independently selected from O, S, N or NH; ! wherein the RQ element may optionally be substituted with 1-4 substituents independently selected from R1, R2, R3, R4 or R5; ! RM and RN independently mean R2; ! R1 is oxo, = NN (R6) 2, = NN (R7) 2, = NN (R6R7), R6 or (CH2) n-Y; ! n is 0, 1 or 2; ! Y is halogen, CN, NO2, CF3, OCF3, OH, SR6, S (O) R6, SO2R6, NH2, NHR6, N (R6) 2, NR6R8, COOH, COOR6 or OR6; either! two elements of R1 at adjacent atoms in the ring taken together form 1,2-methylenedioxy or 1,2-ethylenediox�