COMPOUNDS OF OXYNTHOMODULIN, PHARMACEUTICAL COMPOSITION ON THEIR BASIS, METHODS OF TREATMENT AND PREVENTION OF OBESITY AND ASSOCIATED DISEASES (OPTIONS) AND MEDICINE (OPTIONS)

摘要

1. Compounds of oxyntomodulin of general formula (I)! ! wherein ! X represents ohm 4-14; and! Z represents a sequence of three amino acid residues; ! and S1 represents the amino acid sequence as shown in row A (SEQ ID NO: 1), or the sequence as represented in row A, in which m amino acid residues are replaced by m corresponding amino acid residues 15-37 of row B (SEQ ID NO: 2 ), and t other amino acid residues of row A are replaced by t corresponding amino acid residues from residues 15-24 of row R; and line A, line B and line R (SEQ ID NO: 145) such as shown:! String AAspSerArgArgAlaGlnAspPheValGln 15161718192021222324Stroka VGluGluGluAlaValArgLeuPheIleGluStroka RArgIleGluIleValLysTyrPheValGlyStroka ATrpLeuMetAsnThrLysArgAsnArgAsn 25262728293031323334Stroka VTrpLeuLysAsnGlyGlyProSerSerGly! АAsnIleAla string 353637 ВАlaProPro string! and the compound optionally further comprises an expansion group connected to the amino acid residue at position 37, and the expansion group includes one or more amino acid residues; ! m is an integer of not less than 1; ! t corresponds to 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10; ! as well as a variant or derivative of the compound; ! or its salt or solvate,! provided that if S1 is identical to the sequence of row A, then Z is not a sequence of His Ser Gln. ! 2. The compound according to claim 1, in which t is 0.! 3. The compound according to claim 1, in which t is 5 or more. ! 4. The compound according to claim 1, 2 or 3, in which Z is an amino acid sequence of two amino acid residues, followed by Gln, Asp or Glu. ! 5. The compound according to claim 1, in which the amino acid substitutions from line B include at least one group of at least three followers