ANALOGUES OF THIOCOLCHICOSIDE WITH MYORELAXANT AND ANTI-INFLAMMATORY ACTIVITY

摘要

1. Compounds of the general formula (I)! ! where! R represents hydrogen, methyl or hydroxymethyl. ! 2. A compound selected from:! 3-N-D-xylopyranosyl-3-O-demethoxy-3-aminothiocolchicine; ! 3-N-D-glucopyranosyl-3-O-demethoxy-3-aminothiocolchicine; ! 3-N-D-mannopyranosyl-3-O-demethoxy-3-aminothiocolchicine; ! 3-N-D-arabinopyranosyl-3-O-demethoxy-3-aminothiocolchicine; ! 3-N-D-lixopyranosyl-3-O-demethoxy-3-aminothiocolchicine; ! 3-N-L-ramnopyranosyl-3-O-demethoxy-3-aminothiocolchicine; ! 3-N-L-fucopyranosyl-3-O-demethoxy-3-aminothiocolchicine. ! 3. Pharmaceutical compositions comprising a compound according to claim 1 or 2 in admixture with acceptable carriers and / or excipients. ! 4. The use of compounds according to claims 1 and 2 for the manufacture of medicines with muscle relaxant and anti-inflammatory activity. ! 5. The use of the compounds of formula (II)! ! for the manufacture of medicines with muscle relaxant activity.