APPLICATION OF THIOTROPIA SALTS FOR TREATMENT OF HEAVY FORMS OF PERSISTENT ASTHMA

摘要

1. The use of salts of tiotropium 1! ! where X is a monovalent negative charge anion, a preferred anion is selected from the group consisting of chloride, bromide, iodide, sulfate, phosphate, methanesulfonate, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalate, succinate, benzoate and para-toluenesulfonate, optionally in the form of their hydrates and / or solvates,! to obtain drugs intended for the treatment of severe persistent asthma. ! 2. The use of 1 for the treatment of patients with asthma of severity 4 GINA (Initiative Council for the treatment of asthma, Global initiative for asthma). ! 3. The use according to claim 1 or 2 for the manufacture of a medicament intended for the treatment of severe persistent asthma in patients with persistent symptoms, despite treatment with inhaled corticosteroids. ! 4. The use according to claim 1 or 2 for the manufacture of a medicament intended for the treatment of severe persistent asthma in patients with persistent symptoms, despite treatment with inhalation of β-2 agonists. ! 5. The use according to claim 1 or 2 for the manufacture of a medicament intended for the treatment of severe persistent asthma in patients with persistent symptoms, despite the combined treatment with inhaled corticosteroids and β-2-agonists of prolonged action. ! 6. The use according to claim 1 or 2 for the manufacture of a medicament intended for the treatment of severe persistent asthma in children. ! 7. The use according to claim 1 or 2 for the manufacture of a medicament intended for the supportive treatment of severe persistent asthma and for the prevention of broncho-obstructive symptoms in patients whose symptoms do not respond