DERIVATIVES OF OLIVOMYCIN 1, ANTIBIOTIC OF AUREOLIC ACID GROUP WITH ANTICANCER ACTIVITY, AND METHOD OF PRODUCTION THEREOF

摘要

FIELD: chemistry; pharmacology.;SUBSTANCE: invention refers to derivatives of olivomycin I antibiotic of aureolic acid group with anticancer activity by structural formula as follows, where R⁵ represents hydrogen, C₃-C₁₀-cycloalkyl or C₁-C₄-alkyl with straight or branched hydrocarbon chain, optionally substituted with one or more hydroxyls. Additionally, invention concerns method of production of the specified derivatives, consisting in selective modification of 2'-carbonyl group of olivomycin 1 by reaction with aminooxyacetic acid, followed by amidation reaction of produced intermediate 2'-(carboxymethoxime)olivomycin 1 and related amines condensing agent added.;EFFECT: method of production of antibiotic derivatives with anticancer activity.;2 cl, 5 tbl, 6 ex