FIELD: chemistry.;SUBSTANCE: invention refers to 1,2,4,5-tetrasubstituted imidazole derivatives of general formula (I) , where R1 represents chlorine, bromine, fluorine or hydrogen atom, R2 represents chlorine or bromine atom, A represents nitrogen atom or group CH, X represents sulphur atom or sulphoxide (S=O) group, or sulphonic (SO2) group, Y represents hydrogen atom or methyl, ethyl, n-propyl, isopropyl, n-butyl, tert-butyl group, Z represents CH group, n represents number 1,2 or 3, and pharmacologically acceptable salts of compounds. Besides, the invention concerns a pharmaceutical composition based on the compound of general formula (I), to the compounds of general formulas and and to application of compounds of general formula (I).;EFFECT: new imidazole derivatives being selective modulators of cannabinoid receptors CB1 with high selectivity.;12 cl, 1 tbl, 4 ex
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机译：技术领域：本发明涉及通式（I）的1,2,4,5-四取代的咪唑衍生物。，其中R 1 代表氯，溴，氟或氢原子，R 2 代表氯或溴原子，A代表氮原子或基团CH，X代表硫原子或亚砜（S = O），或磺酸基（SO 2 ），Y代表氢原子或甲基，乙基，正丙基，异丙基，正丁基，叔-丁基，Z代表CH基，n代表1,2或3，以及化合物的药理学可接受的盐。此外，本发明涉及基于通式（I）的化合物的药物组合物，涉及通式为<图像文件=“ 00000021.GIF” he =“ 57” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 79” />和<图像文件=“ 00000022.GIF” he =“ 57” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 66” />并应用于通式（I）的化合物。 ;效果：新的咪唑衍生物是大麻素受体CB 1 的选择性调节剂，具有高选择性。; 12 cl，1 tbl，4 ex
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