SILVER SALT OF N-(6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5H-PYRIMIDINESULPHONE)-N'-ISONICOTINOYLHYDRAZIDE, WHICH EXHIBITS IMMUNOTROPIC, ANTIMICROBIAL, ANTIFUNGAL (ANTIMYCOTIC) ACTIVITY AND MEDICINAL AGENT BASED ON SAID SALT

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to a new silver salt of N-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrimidinesulphone)-N'-isonicotinoylhydrazide, which exhibits immunotropic, antimicrobial, antifungal (antimycotic) activity, obtained by adding silver nitrate to an aqueous suspension of N-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrimidinesulphone)- N'-isonicotinoylhydrazide, thoroughly mixed to a homogeneous state, in molar ratio of hydrazide to silver nitrate from 1:1 to 1:4 in the absence of light until a bulky residue is obtained, which is later separated. Usually N-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrimidinesulphone)-N'-isonicotinoylhydrazide in fine dispersed state is used to obtain the silver salt. Normally, the salt is extracted through filtration, repeated washing with bidistilled water and drying at temperature 50-80°C. The invention also relates to a medicinal agent, containing the silver salt of N-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrimidinesulphone)-N'-isonicotinoylhydrazide as active substance, obtained using the method described above, or a mixture of N-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrimidinesulphone)-N'-isonicotinoylhydrazide and its silver salt in ratio of 1:1 to 4:1, possibly in form of tablets, capsules, ointment, suppositories.;EFFECT: more effective application.;4 cl, 3 tbl, 9 ex