New anthracene dicarboxylic acid imide compounds useful e.g. as photodimerisation product for treating tumors, vat dye, dihydroanthercenebisimde compound and bisanthracene dicarboxylic acid imide compounds

摘要

Anthracene dicarboxylic acid imide compounds (Xa), dihydroanthercenebisimde compound (VI), and bisanthracene dicarboxylic acid imide compounds (Xb), are new. Anthracene dicarboxylic acid imide compounds (Xa) of formulae (I)-(V), dihydroanthracene bisimide compound of formula (VI) and bisanthracene dicarboxylic acid imide compounds (Xb) of formulae (VII)-(XI), are new. X : C 2H 5, 1-butyl, 1-pentyl, 1-hexyl, 1-nonyl, 1-propylbutyl, 1-butlypentyl, 1-hexylheptyl, 1-heptyloctyl, 1-octylnonyl, 1-nonyldecyl, 1-decylundecyl, 2-ethylphenyl, 2,3-dimethylphenyl, 2,5-di-tert-butylphenyl or 2,6-di-isopropylphenyl; and R 1-R 15H, 37C-alkyl (in which 1-10 CH 2groups are substituted by carbonyl group, O, S, Se, Te, cis or trans -CH=CH- (in which one CH group is also substituted by N)), Ctriple boundC, 1,2-, 1,3- or 1,4-substituted phenyl, 2,3-, 2,4-, 2,5-, 2,6-, 3,4- or 3,5 disubstituted pyridine, 2,3-, 2,4-, 2,5- or 3,4-disubstituted thiophene, 1,2-, 1,3-, 1,4-, 1,5-, 1,6-, 1,7-, 1,8-, 2,3-, 2,6- or 2,7-disubstituted naphthalene(in which one or two CH group or carbon is substituted by N), 1,2-, 1,3-, 1,4-, 1,5-, 1,6-, 1,7-, 1,8-, 1,9-, 1,10-, 2,3-, 2,6-, 2,7-, 2,9, 2,10 or 9,10-disubstituted anthracene (in which 1 or 2 CH group or carbon is substituted by N), halo, preferably F, Cl, Br or I, where up to 12 single H atoms of the CH 2groups are substituted by halo, preferably F, Cl, Br, I or CN, or a linear up to 18C-alkyl, in which 1-6 CH 2-groups are substituted by carbonyl, O, S, Se, Te, cis or trans-CH=CH-group (in which one CH unit is also substituted by N), and the free valent of methine group and/or its quaternary carbon atoms are connected pair wise, such that the ring is a cyclohexane ring. Independent claims are included for: (1) the six preparations of (I); (2) preparation of aceanthrene quinone from anthracene and oxalylchloride under the addition of water-free aluminum chloride in sulfur carbon in a molar ratio of 1:5:1.5-1:6:2.5, preferably 1:5.2:2; and (3) preparation of a dye. [Image] [Image] [Image] [Image] [Image] [Image] ACTIVITY : Cytostatic. MECHANISM OF ACTION : None given.