aptamers, which on the hemostasis to a target molecule participating bind

摘要

The present invention relates to an aptamer, the application to a target molecule participating binds to the hemostasis, wherein the aptamer is an aptamer, which binds to the activated protein c, wherein the aptamer with a dissociation constant k_D in the range of ≧ 0,001 nm to ≦ 80 nm of the activated protein c and wherein the aptamer a length in the range of ≧ 20 nucleotides to ≦ 160 nucleotides or wherein the aptamer has a thrombin - binding fusions - aptameter, comprising at least two of thrombin binding aptamers and at least a linker, wherein the at least one left the at least two of thrombin be bound connects aptamers.