New pyrazine compounds useful in the fungicidal agent, for combating plant pathogenic fungus in protecting materials, plants, ground or seeds and to treat cancer

摘要

Pyrazine compounds (I) and their salts are new. Pyrazine compounds of formula (I) and their salts are new. R1, R4halo (preferred), CN, 1-8C alkoxy or phenyl-1-4C alkyl; R21-12C alkyl, 1-10C haloalkyl, 2-10C alkenyl, 2-10C haloalkenyl, 2-10C alkynyl, 2-10C haloalkynyl, 3-6C cycloalkyl, 3-8C cycloalkenyl, 3-12C cycloalkenyl, 3-6C halocycloalkyl, 3-12C halocycloalkenyl, aryl (preferred) or aromatic heterocycle (containing 1-4 R1a group and other than carbon atoms, up to 4 N or 0-2 N, S or O as a ring atoms, where the aromatic groups are 5-10 membered ring system); R1a : CN, nitro, OH, carboxyl, 1-6C alkyl, 2-6C alkynyl, 3-6C cycloalkyl, 3-8C cycloalkenyl, 1-6C alkoxy, 2-6C alkenyloxy, 3-6C alkynyloxy, 3-6C cycloalkoxy, 3-6C cycloalkenyloxy, C(O)R1n, C(O)OR1n, C(S)OR1n, C(O)SR1n, C(S)SR, OC(O)OR1n, 1-6C alkylthio, amino, 1-6C alkylamino, di-1-6C alkylamino, 1-6C alkylene, oxy-1-4C alkylene, oxy-1-3C alkylenoxy, where the divalent groups are bonded to the same atom or at the adjacent atoms, phenyl, naphthyl, 5-10 membered saturated, partially unsaturated or aromatic heterocycle (containing other than the carbon atoms, an up to 4 N or up to 3 N, S or O as a ring atom); R1n : 1-8C alkyl, 3-8C alkenyl, 3-8C alkynyl, 3-6C cycloalkyl or 3-6C cycloalkenyl, where the aliphatic, alicyclic or aromatic groups in R1a and R1n are halogenated partially or completely and carries 1-3 groups of R1b; R1b : halo, CN, nitro, OH, mercapto, amino, carboxyl, alkyl, haloalkyl, alkenyl, alkoxy, haloalkoxy, alkenyloxy, alkynyloxy, alkylthio, alkylamino, dialkylamino, formyl, alkylcarbonyl, alkylsulfonyl, alkylsulfoxyl, alkoxycarbonyl, alkylcarbonyloxy, alkoxycarbonyloxy, aminocarbonyl, aminothiocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkylaminothiocarbonyl, dialkylaminothiocarbonyl, where the alkyl group contains 1-6 carbon atom and the alkenyl- or alkynyl group contains 2-8 carbon atoms, cycloalkyl, cycloalkoxy, heterocyclyl, heterocyclyloxy, where the cyclic system contains 3-10 ring member, aryl, aryloxy, arylthio, aryl-1-6C alkoxy, aryl-1-6C alkyl, hetaryl, hetaryloxy, hetarylthio, where the aryl residue is preferably 6-10 ring members containing 5-6 membered hetaryl residues, where the cyclic systems are partially or completely halogenated and/or substituted by alkyl- or haloalkyl group; R3aryl (preferred) or heteroaryl, containing other than carbon atom, up to 4 N or 0-2 N, S or as a ring atom, where the group is 5-10 membered ring system, containing a group L1 in ortho position to the bonding to the pyridazine-basic unit and at least a further group Lm; L1halo, 1-4C alkyl, 1-4C haloalkyl; L : halo, OH, OCN, CN, nitro, 1-8C alkyl, 1-8C haloalkyl, 2-10C alkenyl, 2-10C haloalkenyl, 2-10C alkynyl, 3-6C cycloalkyl, 3-6C halocycloalkyl, 3-6C cycloalkenyl, 1-8C alkoxy, 1-8C haloalkoxy, 2-10C alkenyloxy, 2-10C alkynyloxy, 3-6C cycloalkyloxy, 3-6C cycloalkenyloxy, amino, 1-4C alkylamino, di-(1-4C)-alkylamino, C(O)-R1z, C(S)-R1z, S(O)n-R1z, 1-8C alkoxyimino- (1-8C)-alkyl, 2-10C alkenyloxyimino-(1-8C)-alkyl, 2-10C alkynyloxyimino-(1-8C)-alkyl, 2-10C alkynylcarbonyl, 3-6C cycloalkylcarbonyl, or 5-10 membered saturated, partially unsaturated or aromatic heterocyclic containing 1-4 heteroatoms of O, N or S; R1z : H, 1-4C alkyl, 1-2C haloalkyl, 1-4C alkoxy, 2-4C alkenyloxy, 2-4C alkynyloxy, where the group R1z is substituted with 1-3 R1b group; n : 0-2; and m : 1-4. Independent claims are included for: (1) the preparation of (I); (2) 1,2-dihydro-pyridazine-3,6-dione compound of formula (II); a fungicidal agent containing a solid or liquid carrier and (I); and (3) a seed containing (I) in a quantity of 1-1000 g/100 kg. [Image] [Image] ACTIVITY : Fungicide; Cytostatic. MECHANISM OF ACTION : None given.