New metallocene compounds are estrogen receptor modulators useful e.g. to treat preferably cancer, manic disorder, gynecomastia and/or female infertility, and to prevent mamma carcinoma

摘要

Metallocene compounds (I), are new. Metallocene compounds of formula (I), are new. M : Fe, Ru, Os, Co, Rh or Ir; R1a-R1d, R2a-R2d : H, alkyl, halo, OH, NH 2, SH, CH 2(CH2) 0-20OH, CH 2(CH2) 0-20NH 2, CH 2(CH 2) 0-20SH, C(O)OH, P(alkyl) rH 3-r, P(aryl)SH 3-s, aromatic, olefin and/or aliphatic carbo- or heterocycle; X, Y1, Z : (-C(R3)(R4)-), (-C(R5)(R6)-) or (-C(=C(R7)(R8))-); either R3-R6 : H, halo, pseudo halo, OH, NH 2, SH, alkyl, alkoxy, alkyl amino, dialkyl amino, alkylthio, aryl, aryl alkyl, aryloxy, arylalkyloxy, heteroaryl or heteroarylalkyl; or R3R4, R5R6 : O, imino or an alkyl substituted imino; R7, R8 : cycloalkyl, cycloalkenyl, aryl, arylalkyl, aryloxy, arylalkyloxy, heteroaryl or heteroarylalkyl (all optionally substituted); and n, m, o : 0-3. Where: n, m and o are not simultaneously 0; and at least one of the groups of X, Y1 or Z is (-C(=C(R7)(R8))-). N.B: r and s are not defined. An independent claim is included for the preparation of (I). [Image] ACTIVITY : Cytostatic; Antimanic; Endocrine-Gen.; Antiinfertility. MECHANISM OF ACTION : Estrogen receptor modulator.