determination of circulating therapeutic antibodies, antigens and antigen - antibody complex in elisa tests

摘要

The present invention relates to a method of determining the efficacy of an antibody immunotherapy in a patient, the method comprising the step of detecting the level of circulating anti-CD52/CD52 complexes in a sample obtained from the patient previously, wherein the level of circulating anti-CD52/CD52 complexes is indicative of a reduction in the amount of therapeutic antibody reaching the target cells.