首页> 外国专利> Preparation of compound, useful to cause immune reactions to prevent e.g. degenerative diseases, cancers, and Parkinson's diseases, where the compound is product of peptides corresponding to intrinsically disordered sequences

Preparation of compound, useful to cause immune reactions to prevent e.g. degenerative diseases, cancers, and Parkinson's diseases, where the compound is product of peptides corresponding to intrinsically disordered sequences

机译:化合物的制备,可用于引起免疫反应以预防例如变性疾病,癌症和帕金森氏病,其中化合物是对应于内在无序序列的肽的产物

摘要

Preparation of a compound to cause immune reactions by introducing the compound into a living organism, where the compound is the product of one or more peptides corresponding to intrinsically disordered sequences determined by the implementation of Foldindex software, and the peptides are irreversible and covalently modified on secondary amino functions of amino acids, is claimed. An independent claim is included for the compound obtained by the process, where the compound contains one or part of the protein sequences comprising one of 58 fully defined 5-93 amino acid sequences (SEQ ID NO: 1-58) given in the specification. e.g. Val Lys Lys Ile Pro Lys Lys Pro (SEQ ID NO: 8) Phe Leu Arg Arg Lys Arg Asp (SEQ ID NO: 24) Arg Glu Lys Ser Lys Lys Tyr Ser (SEQ ID NO: 33) Glu Arg Lys Glu Lys Gly (SEQ ID NO: 36) Glu Lys Lys Lys Lys Ile Thr Val (SEQ ID NO: 49) Leu Arg Ile Lys Lys Lys Lys Glu (SEQ ID NO: 52) Phe Lys Lys Glu Lys Asn (SEQ ID NO: 56) ACTIVITY : Immunomodulator; Cytostatic; Cardiovascular-Gen; Hypotensive; Antiarteriosclerotic; Ophthalmological; Osteopathic; Cerebroprotective; Antiparkinsonian; Neuroprotective; Nootropic; Nephrotropic. MECHANISM OF ACTION : None given.
机译:通过将化合物引入活生物体来制备可引起免疫反应的化合物,其中该化合物是一种或多种肽的产物,这些肽对应于通过Foldindex软件的实施而确定的固有无序序列,并且这些肽不可逆且经共价修饰要求保护氨基酸的仲氨基功能。包括通过该方法获得的化合物的独立权利要求,其中该化合物包含说明书中给出的包含58个完全定义的5-93个氨基酸序列(SEQ ID NO:1-58)之一的蛋白质序列的一部分或一部分。例如Val Lys Lys Ile Pro Lys Lys Pro(SEQ ID NO:8)Phe Leu Arg Arg Lys Arg Asp(SEQ ID NO:24)Arg Glu Lys Ser Lys Lys Tyr Ser(SEQ ID NO:33)Glu Arg Lys Glu Lys Gly (SEQ ID NO:36)Glu Lys Lys Lys Lys Ile Thr Val(SEQ ID NO:49)Leu Arg Ile Lys Lys Lys Lys Glu(SEQ ID NO:52)Phe Lys Lys Glu Lys Asn(SEQ ID NO:56)活动:免疫调节剂;细胞抑制心血管基因降压;抗动脉硬化;眼科整骨;脑保护反帕金森病;具有神经保护作用;促智;嗜肾。作用机理:未给出。

著录项

  • 公开/公告号FR2922769A1

    专利类型

  • 公开/公告日2009-05-01

    原文格式PDF

  • 申请/专利权人 MALINA HALINA;

    申请/专利号FR20070007646

  • 发明设计人 MALINA HALINA;

    申请日2007-10-31

  • 分类号A61K38;A61P25;A61P35;C07K14/47;G01N33/68;

  • 国家 FR

  • 入库时间 2022-08-21 19:07:20

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