NEAR-INFRARED FLUORESCENT PROBE FOR IMAGING LOW-OXYGEN REGION

摘要

PROBLEM TO BE SOLVED: To provide a near-infrared fluorescent probe for non-invasively imaging a low-oxygen region with the low-oxygen region as a target reliably and specifically.;SOLUTION: The near-infrared fluorescent probe for imaging a low-oxygen region comprises: a near-infrared fluorescent dye; a low-oxygen binding part that is activated by reductive metabolism at a low-oxygen region and is bound with a nucleophilic biomolecule; and linker bonding. The near-infrared fluorescent dye can be a cyanin-based dye or a BODIPY-based dye. A low-oxygen bonding part can be a unit containing a nitro aromatic ring of benzene, imidazole, and triazole. Linker bonding can be formed by a chain unit including a functional group by one of polyester, triazole, amide, thioamide, ester, thioester, carbamate, amine, sulfide, ether, and alkyl groups, or their combination. A method of imaging a low-oxygen region uses the near-infrared fluorescent probe for imaging a low-oxygen region.;COPYRIGHT: (C)2010,JPO&INPIT