NEW NOTCH-ORIGIN POLYPEPTIDE, AND BIOMARKER AND REAGENT USING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide an extracellular marker detecting Notch signal transduction.;SOLUTION: A polypeptide (N) which is a new peptide group originating in Notch protein and extracellularly released in the step of nuclear migration of NICD (Notch intracellular cytoplasmic domain) due to the extracellular digestion and the subsequent protein digestion in the membrane during a series of protein digestion of the Notch protein is referred to as a marker. The peptide group (N) is extracellularly released in proportion to the Notch signal depending on presenilin. Thereby, the Notch signal transduction, cell differentiation, cell tumorigenesis, apoptosis, and Alzheimer's diseases etc., can be monitored by detecting the peptide group.;COPYRIGHT: (C)2010,JPO&INPIT