CHEMICAL PREPARATION OF POORLY WATER-SOLUBLE MEDICINE, METHOD FOR PRODUCING THE MEDICINE CHEMICAL PREPARATION AND METHOD FOR PRODUCING DILUTED MEDICINE CHEMICAL PREPARATION

摘要

PROBLEM TO BE SOLVED: To provide a chemical preparation which has an effect for retarding the formation of precipitations, when etoposide which is a poorly water-soluble medicine is made into a diluted medicine chemical preparation having a concentration of an infusion solution level.;SOLUTION: The chemical preparation of the poorly water-soluble medicine obtained by dissolving etoposide into an aqueous ethanol solution, having the precipitation formation-retarding effect when diluted with a physiological salt solution 20 times, is obtained by adding albumin in an amount of ≥0.4 mg/mL to a solution prepared by dissolving the etoposide into 7 to 34 vol.% of anhydrous ethanol, when the medicine chemical preparation is converted as 5 mL of an aqueous ethanol solution medicine preparation.;COPYRIGHT: (C)2010,JPO&INPIT