20-KETO-11BETA-ARYLSTEROIDS AND THEIR DERIVATIVES HAVING AGONIST OR ANTAGONIST HORMONAL PROPERTIES

摘要

PPROBLEM TO BE SOLVED: To solve the problem that the necessity of an anti-progestin compound exhibiting higher specificity is left. PSOLUTION: A cyclic amine-substituted compound such as N-piperidinyl, especially useful when the 4-position of a 11-aryl portion is substituted, is provided, because we have found that it has the reduced possibility of toxicity, not only holds the total molecular characteristics of dimethylamino analogues, but also exhibits to strongly bind to progestin receptors, and has a latent progesterone or anti-progesterone activity. PCOPYRIGHT: (C)2010,JPO&INPIT