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Gastric cancer gene ZNF312b, protein translated from the gene, diagnostic kit, and anticancer drug screening method using the protein
Gastric cancer gene ZNF312b, protein translated from the gene, diagnostic kit, and anticancer drug screening method using the protein
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机译:胃癌基因ZNF312b,从该基因翻译的蛋白质,诊断试剂盒以及使用该蛋白质的抗癌药物筛选方法
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摘要
The present invention relates to a diagnostic marker containing ZNF312b gene and the fragment thereof, a diagnostic method for stomach cancer and a screening method for stomach cancer inducers or inhibitors using the same. ZNF312b gene expression is specifically increased in stomach cancer. And the over-expression or the under-expression of the gene affects activation or inhibition of cell proliferation and tumor formation of a stomach cancer cell line and cell proliferation signal transduction system as well to induce stomach cancer at last. Therefore, ZNF312b marker gene can be effectively used for diagnosis of stomach cancer, construction of a stomach cancer animal model, prevention and treatment of stomach cancer and development of a stomach cancer specific anticancer agent.
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