And collagen scaffold was modified by covalently coupling the graft chain of adhesion molecules, and its application to cardiovascular therapy and breast tissue engineering and the contractile cells

摘要

Improved electrical and mechanical properties biological properties of three-dimensional scaffold to be used, including the adhesion molecules that control reagents and bio-compatible, cell adhesion, apoptosis, differentiation and / or survival, in cell transplantation materials and methods in order to. Can be used in population heart muscle engineering and cardiac cell therapy and cardiovascular medicine / surgery and chest by grafting adhesion molecules to the collagen matrix. Presentation and methods graft simple method of biological reagents or adhesion molecules in the manufacture of scaffolds containing thiol accessible and / or collagen, an amine or carboxyl group.