The magnetic resonance image T1 contrast medium which includes the manganese dioxide nano- particle

摘要

This invention the manganese dioxide which makes T1 of organization decrease (MnO) regards method and the use which use the nano- particle magnetic resonance image (MRI) as the T1 contrast medium. From as for details, as for this invention, it regards diagnostic of the tumor and the like which obtains more minute image than former general T1 emphasis image making use of the magnetic resonance image T1 contrast medium and this magnetic resonance image T1 contrast medium which contain the MnO nano- particle which was covered with the organism compatibility substance which is connected to the bioactive substance for example like target directivity substance such as tumor marker and remedy method. The magnetic resonance image T1 contrast medium of this invention T1 contrast image, during organizing which occurs due to the difference of contrast medium composure classified by organization makes the anatomy image conversion of high resolution possible embossing there being a permeation character in the cell where you have lived, it is possible to reflect the degree of distribution of the cell. In addition, when the target factor which is connected with diseased unique sign factor is acquired to the surface of the nano- particle, can the magnetic resonance image T1 contrast medium of this invention, use as the contrast medium for the diagnosing and remedy the target oriented of various sicknesses of the tumor and the like.