Solid pharmaceutical formulation of uniform dispersion of active ingredient having pH-dependent solubility

摘要

The present invention relates to solid pharmaceutical formulations of a homogeneous dispersion of at least one active principle which possesses pH-dependent solubility, e.g. 1-[4-chloroanilino]-4-[4-pyridylmethyl]phthalazine, or a pharmaceutically acceptable salt thereof, to solid dosage forms comprising said solid pharmaceutical formulations, to methods of preparing said solid pharmaceutical formulations and said solid dosage forms, to uses of said solid pharmaceutical formulations, alone or in combination with one or more pharmaceutically active compounds, for the manufacture of a medicament for the treatment especially of a proliferative disease, such as cancer, and to a method of treatment of a proliferative disease, such as cancer.