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Method for inducing cell-mediated immune response and parenteral vaccine formulation therefor
Method for inducing cell-mediated immune response and parenteral vaccine formulation therefor
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机译:诱导细胞介导的免疫反应的方法及其肠胃外疫苗制剂
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摘要
A method of inducing either a TH1 polarised immune response, a TH2 polarised immune response or a combined TH1 and TH2 response to an antigen and associated vaccine formulations are disclosed. A method is provided for inducing a polarised TH1 response by parenteral administration of microparticles sized such that at least 50 % of the microparticles are less than 5 mu m, the microparticles containing antigen entrapped or encapsulated by a biodegradable polymer. Additionally, a method is provided for inducing a polarised TH2 response by parenteral administration of nanoparticles sized such that at least 50 % of the nanoparticles are less than 600 nm, the nanoparticles containing antigen entrapped or encapsulated by a biodegradable polymer. Vaccine formulations containing the B.pertussis antigens PTd, FHA or a combination of PTd and FHA are provided.
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