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METHOD FOR INDUCING A CELL-MEDIATED IMMUNE RESPONSE AND PARENTERAL VACCINE FORMULATIONS THEREFOR
METHOD FOR INDUCING A CELL-MEDIATED IMMUNE RESPONSE AND PARENTERAL VACCINE FORMULATIONS THEREFOR
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机译:诱导细胞介导的免疫反应的方法和腹膜炎疫苗制剂
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摘要
A method of inducing either a T H1 polarised immune response, a T H2 polarised immune response or a combined T H1 and T H2 response to an antigen and associated vaccine formulations are disclosed. A method is provided for inducing a polarised TH 1 response by parenteral administration of microparticles sized such that at least 50% of the microparticles are less than 5 µm, the microparticles containing antigen entrapped or encapsulated by a biodegradable polymer. Additionally, a method is provided for inducing a polarised T H2 response by parenteral administration of nanoparticles sized such that at least 50% of the nanoparticles are less than 600 nm, the nanoparticles containing antigen entrapped or encapsulated by a biodegradable polymer. Vaccine formulations containing the B.pertussis antigens PTd, FHA or a combination of PTd and FHA are provided.
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