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RNA interference mediated inhibition of Aurora kinase B and its combination as anti-cancer therapy
RNA interference mediated inhibition of Aurora kinase B and its combination as anti-cancer therapy
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机译:RNA干扰介导的Aurora激酶B抑制作用及其组合作为抗癌治疗
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摘要
This invention relates to the use of short nucleic acid molecules that modulate Aurora-B kinase (AurkB) expression. The invention includes compounds, compositions and methods useful for the modulation of expression and activity of genes involved in the AurkB pathway. In one embodiment, the present invention provides short nucleic acid molecules, such as siRNA, which can be used in treating, preventing, or inhibiting cancer, and any other proliferative disease, trait or condition, which respond to a reduction in AurkB expression in a cell or tissue. Such short nucleic acid molecules can be used alone or in combination with other treatments or therapies, including short nucleic acid molecules that modulate expression of EGFR.
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