Using their derivatives and conjugates of disorazoles with cell-binding molecules, novel disorazole derivatives and processes for their preparation

摘要

The present invention provides derivatives and their conjugates of disorazoles with peptides, proteins, hormones, and cell-binding molecules such as antibodies and blood proteins. The present invention provides a process for preparing disorazole derivative disorazole such new and derivative disorazole further. For the treatment of pathophysiological conditions and / or physiologically in mammals, these compounds can be used as a medicament for the treatment of a variety of particular tumors.