It is refined and optionally preparation manner of the TSH receptor product which the indicator is done, the new radioactive iodic indicator TSH receptor product, and behavior it does same as natural person

摘要

(57) Abstract With amino acid array of the functional TSH receptor and the peptide residue which it can join to solid-state phase, is removed choice from amino acid array of the functional TSH receptor the appropriate protease, for example by the operation of factor Xa the rearrangement fusion TSH receptor (fusion TSHR) which possesses the addition amino acid array which is interposed to be prepared, this fusion receptor is joined by appropriate solid-state phase, the fusion receptor where the mixture component is excluded by cleaning, to indicator is converted optionally with join configuration, joins to solid-state phase, with the enzyme resolution which uses the protease from the fusion receptor residue which is joined to solid-state phase removalPreparation manner of the rearrangement TSH receptor product (rTSHR product) where the rTSHR product where it was done, and, was obtained and was refined is recovered, was refined. New it was refined, in order or refinement and the human rTSHR product which the indicator is done, to grant oral magnanimity, or it can be used in order to offer the new immunity sinkage assay for measuring the anti- TSHR self antibody.