At the time for the liposome of dokisorubishin where at the time

摘要

PROBLEM TO BE SOLVED: To obtain the subject kit capable of being easily prepared, having small particle size of liposome effectively containing agents and containing no aggregates by allowing the kit to include a liposome membrane-forming material comprising a phospholipid composition containing phospholipid, liposome zeta-potential-increasing agent, etc., a cationic agents and an aqueous medium. ;SOLUTION: (A) A phospholipid composition prepared by dissolving (i) a liposome membrane-forming material comprising a phospholipid, e.g. phosphatidyl choline with (ii) a liposome zata-potential-increasing agent, e.g. oleic acid having a negative electric charge, sodium cholesterol sulfate, etc., enclosed in a vessel under an inactive gas atmosphere is added to (B) a cationic agent such as doxorubicin, vincristine, daunorubicin or the like when it is used, and the obtained solution is added to (C) an aqueous medium suitable for intravenus injections, e.g. a sodium chloride solution having 0.9 wt.% concentration, Ringer's solution or the like.;COPYRIGHT: (C)2000,JPO