Central nervous system disorder therapeutic agent and method for treating central nervous system disorder

摘要

EphA receptor ligands such as ephrin-A multimers, for example, ephrin-A1 multimers that multimerize ephrin-A1-Fc fused to IgG (Fc) fragment at the C-terminus of the extracellular domain of ephrin-A1 The ephrin-A1 multimer multimerized using the Coiled-Coil domain site (hTSP5cc) derived from the body and human thrombospondin 5 is injected into the lateral ventricle or striatum to differentiate neural stem cells in the central nervous system. It proliferates and migrates, and recovers damage caused by central nervous degeneration such as Parkinson's disease and striatal nigra degeneration. [Selection] Figure 14